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Anticoagulants: Phenobarbital lowers the plasma levels of dicumarol (name Beforehand used: bishydroxycoumarin) and will cause a lower in anticoagulant exercise as calculated from the prothrombin time. Barbiturates can induce hepatic microsomal enzymes causing elevated metabolism and decreased anticoagulant response of oral anticoagulants (e.Nitschk